Abnormal spontaneous brain activity in females with autism spectrum disorders

Objectives To date, most studies on autism spectrum disorder (ASD) have focused sample sets that were primarily or entirely composed of males; brain spontaneous activity changes in females remain unclear. The purpose this study was to explore the neural with ASD. Methods In study, resting-state functional magnetic resonance images (rs-fMRI) 41 ASD and typically developing (TD) controls obtained from ABDIE database. amplitude low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) two groups calculated detect activity. A independent t -test used analyze differences between TD a p- value <0.05 considered statistically significant after false discovery rate (FDR) correction. Pearson correlation analysis conducted social responsiveness scale (SRS) scores local significantly different regions. Results Compared group, values ReHo increased left superior temporal gyrus (STG), while decreased frontal (SFG), middle occipital (MOG), bilateral parietal lobule (SPL), precuneus group. Correlation showed right positively correlated total SRS, communication, autistic mannerisms. Conclusion Spontaneous involved multiple regions related clinical characteristics. Our results may provide some help for further exploring neurobiological mechanism